The article "Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial", featured on the cover of Stroke's April 2025 issue (originally published March 17, 2025), highlights uric acid (UA) as a promising cerebroprotective agent for ischemic stroke. The study shows that UA offers protection across key biological variables, including sex, age, and comorbidities, suggesting its potential for broader therapeutic use in stroke treatment and warranting further human clinical trials.