The exceptional contributions of SPAN Investigators and collaborators at the International Stroke Conference (ISC) 2025, held in Los Angeles from February 4-7, are proudly highlighted here. With a strong presence throughout the event, SPAN showcased cutting-edge research that underscores a commitment to excellence and collaboration in the stroke science community. This section celebrates the talks, abstracts, and posters presented, reflecting the collective impact of SPAN’s work. These groundbreaking contributions are featured with the goal of advancing further innovation through continued partnership.